I know it's been a bit over a week more than I was hoping it would take... but I just came off a two odd hour play, and I'm impressed. Performance is good, even with multiple companions running on one script.
I've got two running on it actively without issue. I plan to up it to three and see how that works.
Thus far the biggest hurdle to release has been the game itself. Testing out in the wasteland is very difficult because of the constant crashes. In more confined spaces, though, they seem to perform excellent; whatever that's worth.
Went into and out of the Strip by gate, and again there were no fights breaking out. There have been no random attacks on non-hostiles, and since I instituted the last piece of code for the combat end block of the script, there haven't been any issues with stoppages after the fight, either.
Some issues in delays on companions following you do persist. Some of the levels of Vault 22, for example, wouldn't let them follow me in. Once I was in, they took an alternate path to try to catch up, and ended up getting lost. When I returned to the entrance to leave, though, they were right there and still following.
Similarly, no companions - even ED-E - were willing to follow me into the Lucky 38 lounge/restaurant/whatever you want to call it. There's a delay following from House's penthouse to the Casino, but they do eventually make it down. No issues whatsoever going from casino level to presidential suite and back; so there shouldn't be any problems with them working with your new home.
A few issues here and there in Freeside; judging by their behavior, I'd say it's shoddy navmeshing again. Most of the tight spaces between rubble don't seem to be 'meshed at all - probably laziness on the devs' part. Companions always come around in the valid navmesh and catch up shortly.
Obviously I haven't played through the entire game, all its quests, and every interior cell that the player could possibly find themselves interacting with, so I'm sure there are still problems lurking about, but I think this should probably do for an initial release.